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Email this article Pathological fatigue in chronic liver disease and tool for its assessment –experts’ decision
Abstract
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Chronic fatigue is a widespread phenomenon, impacting almost 20% of the population. According to the literature, pathological fatigue represents the most common complaint in patients with chronic liver disease.
The aim of study Pathological fatigue is the most commonly encountered symptom in patients with chronic liver disease, and it has a significant impact on their quality of life. It’s important to measure pathological fatigue in patients with chronic liver disease in the clinical setting.
Discussing existing questionnaires for assessment of pathological fatigue and choosing most clear, understandable and comfortable questionnaire scale for initiation of study.
Planned Study Settings and Population
Cohort based study will be conducted in 10 post-soviet countries The following groups of chronic liver disease patients will be selected: all cholestatic liver diseases, autoimmune hepatitis, chronic viral hepatitis, alcoholic liver damage, non-alcoholic liver fatty disease and primary sclerosing cholangitis. Selected and translated questionnaire will be filled during patients visit to the physician. Results from the survey will be analyzed, summarized and statistically processed.
Conclusion
Despite of the etiotropic treatment of chronic liver diseases, pathological fatigue still remains. Improving quality of life among chronic liver disease patients is of great importance. Fatigue Assessment Scale is the best tool for assessing pathological fatigue.
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Adams RD, Victor M, Ropper AH. Fatigue, asthenia, anxiety and depressive reactions. Principles of Neurology. 6. New York: McGraw-Hill; 1997. pp. 497–507.
Cauch-Dudek K, Abbey S, Stewart DE, Heathcote EJ. Fatigue in primary biliary cirrhosis. Gut. 1998;43:705–10. [PMC free article] [PubMed]
Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet. 2004;363:978–88. [PubMed]
Coughlan B, Sheehan J, Hickey A, Crowe J. Psychological well-being and quality of life in women with an iatrogenic hepatitis C infection. Br J Health Psychol. 2002;7:105–16. [PubMed]
Czaja AJ, Freese DK. Diagnosis and treatment of autoimmune hepatitis. Hepatology. 2002;36:479–97.[PubMed]
Dirks M et al. Neuropsychiatric symptoms in hepatitis C patients resemble those of patients with autoimmune liver disease but are different from those in hepatitis B patients. J ViHepatitis , 2018(ePub Aug 18)
Ferrari R, Pappas G, Agostinelli D, et al. Type 1 autoimmune hepatitis: Patters of clinical presentations and differential diagnosis of the ‘acute’ type. QJM. 2004;97:407–12. [PubMed]
Fisk J, Ritvo PG, Ross L, Haase DA, Marrie TJ, Schlech WF. Measuring the functional impact of fatigue: Initial validation of the fatigue impact scale. Clin Infect Dis. 1994;18(Suppl 1):S79–83. [PubMed]
Forton DM, Allsop JM, Main J, Foster GR, Thomas HC, Taylor-Robinson SD. Evidence for a cerebral effect of the hepatitis C virus. Lancet. 2001;358:38–9. [PubMed]
Foster GR, Goldin RD, Thomas HC. Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis. Hepatology. 1998;27:209–12. [PubMed]
Huet PM, Deslauriers J, Tran A, Faucher C, Charbonneau J. Impact of fatigue on the quality of life in patients with primary biliary cirrhosis. Am J Gastroenterol. 2000;95:760–7. [PubMed]
Kenny-Walsh E Irish Hepatology Research Group. Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. N Engl J Med. 1999;340:1228–33. [PubMed]
Kramer L, Bauer E, Funk G, et al. Subclinical impairment of brain function in chronic hepatitis C infection. J Hepatol. 2002;37:349–54. [PubMed]
Krawczyk M et al. Effects of liver transplantation (LTx) on health-related quality oflife (HRQoL) in patients with PBC.Journal of Hepatology 2018 vol. 68:S382
Kumar D, Tandon RK. Fatigue in cholestatic liver disease – a perplexing symptom. Postgrad Med J. 2002;78:404–7. [PMC free article] [PubMed]
McDonald J, Jayasuriya R, Bindley P, Gonsalvez C, Gluseska S. Fatigue and psychological disorders in chronic hepatitis C. J GastroenterolHepatol. 2002;17:171–6. [PubMed]
Milkiewicz P, Heathcote EJ. Fatigue in chronic cholestasis. Gut. 2004;53:475–7. [PMC free article][PubMed]
Morgello S. The nervous system and hepatitis C virus. Semin Liver Dis. 2005;25:118–21.[PubMed]
Nwankwo C et al. C-EDGE treatment experienced: Effect of 12week oral regimens ofElbasvir and Grazoprevir on health related quality of life in priortreatment experienced patients with chronic hepatitis C infection. Journal of Hepatology 2018 vol. 68:S283
Obermayer-Straub P, Strassburg CP, Manns MP. Autoimmune hepatitis. J Hepatol. 2000;32(Suppl 1):181–97. [PubMed]
Poynard T, Cacoub P, Ratziu V, et al. Fatigue in patients with chronic hepatitis C. J Viral Hepat. 2002;9:295–303. [PubMed]
Rodger AJ, Jolley D, Thompson SC, Lanigan A, Crofts N. The impact of diagnosis of hepatitis C virus on quality of life. Hepatology. 1999;30:1299–301. [PubMed]
Schwartz JE, Jandorf L, Krupp LB. The measurement of fatigue: A new instrument. J Psychosom Res. 1993;37:753–62. [PubMed]
Swain MG Fatigue in chronic disease. ClinSci (Lond) 2000;99:1–8. [PubMed]
Weissenborn K, Krause J, Bokemeyer M, et al. Hepatitis C virus infection affects the brain-evidence from psychometric studies and magnetic resonance spectroscopy. J Hepatol. 2004;41:845–51. [PubMed]
Wessely S, Pariante C. Fatigue, depression and chronic hepatitis C infection. Psychol Med. 2002;32:1–10. [PubMed]
Younossi ZM, Boparai N, Price LL, Kiwi ML, McCormick M, Guyatt G. Health-related quality of life in chronic liver disease: The impact of type and severity of liver disease. Am J Gastroenterol. 2001;96:2199–205. [PubMed]
Younossi Z et al. The impact of sustained virologic response on severe fatigue inpatients with chronic hepatitis C: The role of HCV viremia andco-morbidities. Journal of Hepatology 2018 vol. 68:S531
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