The treatment of tongue squamous cell carcinoma in rats

Abstract

Background. This paper concerns the development of a local drug delivery system for destroying the residual tumor cells following the excision of squamous cell carcinoma of the tongue.

Methods. The local drug delivery system is presented as a two-layer multicomponent gel (MCG) based on fibrin. The internal layer of MCG that directly contacted the surface of the wound contained Cisplatin, which were placed on collagen microcarrier CultiSpher-S. The external layer of MCG was composed with microcarrier CultiSpher-S containing Cisplatin and freeze-dried bone marrow stem cells. The efficacy of MCG was tested in a rat model of squamous cell carcinoma of the tongue created with 4-Nitroquinoline 1-oxide (4NQO).

Results. The targeted drug delivery system based on MCG that we developed has shown high efficacy for the treatment of squamous cell carcinoma of the tongue in rats. In 75% of animals with the model of squamous cell carcinoma of the tongue that were treated with MCG, a noticeable suppression of tumor growth was evident throughout 90 days without the phenomenon of tumor recurrence.

Conclusion.  Local drug delivery system based on the MCG has demonstrated efficiency in preventing residual tumor cells caused by local recurrence.