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VDR Fokl rs2228570 SNP in Autoimmune Thyroiditis


 
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1. Title Title of document VDR Fokl rs2228570 SNP in Autoimmune Thyroiditis
 
2. Creator Author's name, affiliation, country Aleena Parveen Shaikh
 
2. Creator Author's name, affiliation, country Rajneesh Khurana
 
2. Creator Author's name, affiliation, country Megi Inaishvili
 
2. Creator Author's name, affiliation, country Nameera Parveen Shaikh
 
2. Creator Author's name, affiliation, country Salome Glonti
 
2. Creator Author's name, affiliation, country Nino Kedelidze
 
2. Creator Author's name, affiliation, country Irina Nakashidze
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) Autoimmune Thyroiditis, Vitamin D polymorphism, FokI, rs2228570.
 
4. Description Abstract

Autoimmune thyroiditis disease (AITD) is a widespread autoimmune pathology. Notably, Genetics factors have a kye contribution to the clinico-pathogenesis of AITD. It's suggested that several immune-related genes have been implicated in genetic susceptibility to AIT.  Vitamin D receptor (VDR) and its system is involved in an orchestrated mechanism of inflammatory response that leads to autoimmunity. In this review, we summarize together the VDR Fokl rs2228570 SNP in autoimmune thyroiditis. Based on the literature review, we have concluded that rs2228570 SNP may have susceptibility and predisposition to develop AITD.

 
5. Publisher Organizing agency, location Ivane Javakhishvili Tbilisi State University
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 2022-12-30
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://tcm.tsu.ge/index.php/TCM-GMJ/article/view/381
 
11. Source Title; vol., no. (year) Translational and Clinical Medicine - Georgian Medical Journal; Vol 7, No 4 (2022): Translational and Clinical Medicine - Georgian Medical Journal
 
12. Language English=en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2022 Translational and Clinical Medicine - Georgian Medical Journal