The Level of Endothelin-1 as a Risk Factor for Complications of Acute Epididymitis

Lytvynets Yevhen, Balabanyk Vasyl


Background: Acute epididymitis is an inflammation of the epididymis. It mostly occurs unilaterally and may spread to the testis (‘epididymoorchitis’) if untreated. In this research, there was made an attempt to clarify the diagnostic and prognostic significance of changes of the endothelin-1 (Et-1) content in the blood plasma of the patients, suffering from acute epididymitis in
connection with violation of blood circulation in testis with an appendage.

Materials and Method: To determine the concentration of Et-1, the method of immune-enzyme analysis was used. A significant increase of the Et-1 concentration was revealed in all the examined patients before treatment.

Results and Discussion: In the preoperative period, in 43% of patients with irreversible complications (lack of blood flow to a testicle or appendage, the Doppler-signal) the high concentration of Et-1 remained to the 7th day (25,8 ± 3,2 ng/ml, exceeding the norm by 2,5 times), which indicated the irreversible microcirculatory disorders in the testicle (appendage), probably because of the increasing of vasoconstriction of blood vessels. In 57% of patients, there was no development of complications, ischemic processes were reversible, and under this, the concentration of Et-1 gradually decreased, and until the 14th day, it was up to 5,8 ± 0,6 ng/ml, returning to the normal range.

Conclusion: The dynamics of change of Et-1 concentration in blood plasma indicates the reversibility of metabolic disorders, related to ischemia of the testicle appendage tissue, as well as the diagnostic and prognostic significance of this factor determination concerning the risk of complications development.


acute epididymitis; endothelial dysfunction; endothelin-1; doppler; predicting complications;

Full Text:



Michel V, Pilatz A, Hedger MP, Meinhardt A. Epididymitis: revelations at the convergence of clinical and basic sciences. Asian Journal of Andrology. 2015; 17: 756-63.

Pilatz A, Hossain H, Kaiser R, et al.: Acute epididymitis revisited: impact of molecular diagnostics on etiology and contemporary guide line recommendations. European Urology 2015; 68: 428-35.

Luzzi GA, O’Brien TS. Acute epididymitis. BJU Int. 2001; 87 (8): 747-55.

Vatutin NT, Kalinkina NV, Demidova AL. Endothelins and the results of multicenter research. Ukrainian journal of Cardiology. 2006; 1: 101-5.

Abrahamovim OO, Faynik AF, Nechaj OV. The mechanisms of development of endothelial dysfunctions and its role in the pathogenesis of coronary heart disease. Ukrainian journal of Cardiology. 2007;. 1: 81-7.

Lytvynets YeA, Vintoniv OR, Kostenko LV. Color Doppler as method of detection of vascular erectile dysfunction. Galician doctors magazine. 2013; 1: 34-6.

Draun M, Sommer F, Lehmacher W. Erectile dysfunction. Are interdisciplinary diagnosis and therapy necessary? Dtsch.Med.Wochenschr. 2004; 38 (3): 227-31.

Klimova YM, Kordon TI, Groma VG. The dynamics of endothelin-1 level and the development of postoperative complications in the patients, having been operated on colorectal cancer. Oncology. 2011; 13 (1): 247-50.

Gozmakov OA. The system of endothelin peptide: the mechanisms of endovascular pathology. Cardiology. 2000; 1 (32): 9.

Klimova OM, Kryvorotko IV, Kordon TI. The diagnostic significance of indexes of immunoreactivity for prognosis impossibility of anastomoses in patients suffering from colorectal cancer. Kharkiv surgical school. 2011; 1 (46): 15-20.

Filayeva JA, Tenchurina TG. The homeostatic peculiarities of angiogenic factors during wound healing with hypertrophic scar after mammoplastic. The modern problems of science. 2007; 2: 73-7.

Pivovar SN. The dynamics of endothelin-1 level and functional state parameters of heart in patients with complicated course of myocardial infarction. Ukrainian medical journal. 2000; 4: 140-3.

Carncek P, Stewart DJ. Immunoreactive endothelin in human plasma: marced elevation in patients in cardivasculary shok . Biochem Biophys Res Commun. 1989; 161: 562-7.

Berezhna NM. The role of immunity system cells in the microenvironment of the tumor. Oncology. 2009; 11(39): 6-17.

Eltze E, Wild PJ, Wülfing C [et al.] Expression of the endothelin axis in noninvasive and superficially invasive bladder cancer: relation to clinicopathologic and molecular prognostic parameters. Eur. Urol. 2009; 56 (5): 837-45.



  • There are currently no refbacks.


Become a REVIEWER 


ISSN: 2346-8491 (online)