Pathological fatigue in chronic liver disease and tool for its assessment –experts’ decision

Pati Gabunia, David Jones, Svetlana Turcan, Alexander Nersesov, Maryna Shcherbynina



Chronic fatigue is a widespread phenomenon, impacting almost 20% of the population. According to the literature, pathological fatigue represents the most common complaint in patients with chronic liver disease.

The aim of study Pathological fatigue is the most commonly encountered symptom in patients with chronic liver disease, and it has a significant impact on their quality of life. It’s important to measure pathological fatigue in patients with chronic liver disease in the clinical setting.


Discussing existing questionnaires for assessment of pathological fatigue and choosing most clear, understandable and comfortable questionnaire scale for initiation of study.

Planned Study Settings and Population

Cohort based study will be conducted in 10 post-soviet countries The following groups of chronic liver disease patients will be selected: all cholestatic liver diseases, autoimmune hepatitis, chronic viral hepatitis,  alcoholic liver damage, non-alcoholic liver fatty disease and primary sclerosing cholangitis. Selected and translated questionnaire will be filled during patients visit to the physician. Results from the survey will be analyzed, summarized and statistically processed.


Despite of the etiotropic treatment of chronic liver diseases, pathological fatigue still remains. Improving quality of life among chronic liver disease patients is of great importance. Fatigue Assessment Scale is the best tool for assessing pathological fatigue.


Chronic fatigue. Liver diseases, Assessment tools

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