Diagnostic methods of bone metastasis in patients with breast cancer

Mariam Tevzadze, Branislav Jeremic, Sopio Kakhadze, Mikhael Baramia, Tatia Aleksishvili


Breast cancer is the most commonly occurring cancer in women population. 70% of patients with breast cancer have evidence of skeletal involvement Early detection of bone metastasis is very important for accurate staging, optimal treatment as well as prognosis of patients with cancer. In the last several decades various radiologic and nuclear medicine tools have been developed and extensively employed in the detection of bone metastasis, including those of breast cancer. Owing to wide spread availability of these technologies and incidence of breast cancer patients, many of which develop bone metastasis during the course of the disease. This paper reviews major aspects of diagnostic methods of bone metastasis in patients with breast cancer. It describes the available imaging methods to diagnose bone metastasis and its utility without having formal comparison between these technologies.


Bone metastases; Breast cancer; Nuclear medicine diagnostic; SPECT/CT; PET/CT MRI; CT; X-ray.

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