Diagnostic methods of bone metastasis in patients with breast cancer

Mariam Tevzadze, Branislav Jeremic, Sopio Kakhadze, Mikhael Baramia, Tatia Aleksishvili

Abstract


Breast cancer is the most commonly occurring cancer in women population. 70% of patients with breast cancer have evidence of skeletal involvement Early detection of bone metastasis is very important for accurate staging, optimal treatment as well as prognosis of patients with cancer. In the last several decades various radiologic and nuclear medicine tools have been developed and extensively employed in the detection of bone metastasis, including those of breast cancer. Owing to wide spread availability of these technologies and incidence of breast cancer patients, many of which develop bone metastasis during the course of the disease. This paper reviews major aspects of diagnostic methods of bone metastasis in patients with breast cancer. It describes the available imaging methods to diagnose bone metastasis and its utility without having formal comparison between these technologies.


Keywords


Bone metastases; Breast cancer; Nuclear medicine diagnostic; SPECT/CT; PET/CT MRI; CT; X-ray.

Full Text:

PDF

References


World Heals Organization (2018) www.who.int

P. Todua, R. Shakarashvili, M. Beraia „MRI of the spine and spinal cord“ establishment “Science” Tbilisi 2001, ISBN 9928

M. Tevzadze, T. Aleksishvili “Radionuclide Diagnostic results 5 year after treatment patients with breast cancer” "Georgian Journal of Radiology" issue 3-4 (46-47) Tbilisi 2018

Longo V, Brunetti O, D’Oronzo S, Ostuni C, Gatti P, Silvestris F. Bone metastases in hepatocellular carcinoma: an emerging issue. Cancer Metastasis Rev. 2014;33:333–342.

Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Mark MT, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S. Tumour exosome integrins determine organotropic metastasis. Nature. 2015 Nov;527(7578):329-35.

Martin P. Sandler, R. Edward Coleman, James A. Patton, Frans J. Th. Wickers, Alexander Gottschalk “Diagnosic Nuklear medicine Martin” (2003) by Lippincott Williams &Wilkines PA 19106 USA

Martin Dunitz I. Fogelman, M.N. Maisey, S.E.M. Clarke “An Atlas of Clinical Nuclear Medicine” UK 1996 ISBN 1-85317-140-9

Salmon JM, Kilpatrick SE. Pathology of skeletal metastases. Orthopedic Clinics of North America. 2000 Oct 1;31(4):537-44.

Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer treatment reviews. 2001 Jun 1;27(3):165-76.

Nystrom JS, Weiner JM, Heffelfinger-Juttner J, Irwin LE, Bateman JR, Wolf RM. Metastatic and histologic presentations in unknown primary cancer. InSeminars in oncology 1977; 4(1):53-8.

Fleury V, Ferrer L, Colombié M, Rusu D, Le Thiec M, Kraeber-Bodéré F, Campion L, Rousseau C. Advantages of systematic trunk SPECT/CT to planar bone scan (PBS) in more than 300 patients with breast or prostate cancer. Oncotarget. 2018 Aug 3;9(60):31744.

Beheshti M, Langsteger W, Fogelman I. Prostate cancer: role of SPECT and PET in imaging bone metastases. InSeminars in nuclear medicine 2009 Nov 1 (Vol. 39, No. 6, pp. 396-407). WB Saunders.

Yang HL, Liu T, Wang XM, Xu Y, Deng SM. Diagnosis of bone metastases: a meta-analysis comparing 18 FDG PET, CT, MRI and bone scintigraphy. European radiology. 2011 Dec 1;21(12):2604-17.

Niikura N, Costelloe CM, Madewell JE, Hayashi N, Yu TK, Liu J, Palla SL, Tokuda Y, Theriault RL, Hortobagyi GN, Ueno NT. FDG-PET/CT compared with conventional imaging in the detection of distant metastases of primary breast cancer. The oncologist. 2011 Aug;16(8):1111.

Yang HL, Liu T, Wang XM, Xu Y, Deng SM. Diagnosis of bone metastases: a meta-analysis comparing 18 FDG PET, CT, MRI and bone scintigraphy. European radiology. 2011 Dec 1;21(12):2604-17.

Eubank WB, Mankoff DA. Evolving role of positron emission tomography in breast cancer imaging. InSeminars in nuclear medicine 2005 Apr 1 (Vol. 35, No. 2, pp. 84-99). WB Saunders.

Abe K, Sasaki M, Kuwabara Y, Koga H, Baba S, Hayashi K, Takahashi N, Honda H. Comparison of 18 FDG-PET with 99m Tc-HMDP scntigraphy for the detection of bone metastases in patients with breast cancer. Annals of nuclear medicine. 2005 Oct 1;19(7):573-9.

Gralow JR, Biermann JS, Farooki A, Fornier MN, Gagel RF, Kumar R, Litsas G, McKay R, Podoloff DA, Srinivas S, Van Poznak CH. NCCN task force report: bone health in cancer care. J Natl Compr Canc Netw. 2013 Aug 1;11(Suppl 3):S1-50.

Wu LM, Gu HY, Zheng J, Xu X, Lin LH, Deng X, Zhang W, Xu JR. Diagnostic value of whole‐body magnetic resonance imaging for bone metastases: a systematic review and meta‐analysis. Journal of Magnetic Resonance Imaging. 2011 Jul;34(1):128-35.

Effenberger KE, Schroeder C, Eulenburg C, Reeh M, Tachezy M, Riethdorf S, Vashist YK, Izbicki JR, Pantel K, Bockhorn M. Disseminated tumor cells in pancreatic cancer—an independent prognosticator of disease progression and survival. International journal of cancer. 2012 Aug 15;131(4):475-83.

Bellamy EA, Nicholas D, Ward M, Coombes RC, Powles TJ, Husband JE. Comparison of computed tomography and conventional radiology in the assessment of treatment response of lytic bony metastases in patients with carcinoma of the breast. Clinical radiology. 1987 Jul 1;38(4):351-5.

Kayser K, Brokenfeld S, Djenouni, et al. Analysis of texture and ob-jects in microscopic images. Diagn Pathol (2015); 2015-1:14.

Rybak LD, Rosenthal DI. “Radiological imaging for the diagnosis of bone metastases”. Q J Nucl Med.( 2001);45:53–64.


Refbacks

  • There are currently no refbacks.




 

Become a REVIEWER 

 

ISSN: 2346-8491 (online)