Evolving Threats: A Review of Major Viral Pandemics from the Spanish Flu to COVID-19

Marika Ramishvili, Gia Gobadze, Avtandil Machavariani, Giorgi Menabde, Marika Zurmukhtashvili

Abstract


Backgroud: Viral pandemics have historically posed significant challenges to global health, economies, and societal structures. This review meticulously synthesizes findings from scholarly articles that examine various viral pandemics, focusing on those caused by influenza viruses and coronaviruses, including notable examples such as SARS, MERS, and the COVID-19 outbreak.

Aim:  The study aimed to review viral pandemics, examining their historical context, causes, transmission dynamics, and control measures, to  provide a comprehensive understanding of their shared characteristics and the responses they elicited from health systems around the world

Methods:  A comprehensive search was conducted using PubMed and Google Scholar databases, focusing on English-language articles published between 1990 and 2024. The search utilized specific keywords, including "pandemic," "respiratory viruses," "coronavirus," “covidpandemic” to identify relevant studies and reviews.

Results: The Spanish flu of 1918, known for being one of the most lethal pandemics in recorded history, serves as a powerful reminder of the severe consequences that can arise from poorly understood pathogens and underdeveloped healthcare infrastructure. This pandemic led to an estimated 50 million fatalities globally, highlighting the crucial need for preparedness. Subsequent pandemics, like the Asian flu in 1957, the Hong Kong flu in 1968, and the Swine flu in 2009, illustrated the importance of timely interventions, robust surveillance networks, and effective vaccination strategies to control viral transmission. The emergence of MERS and SARS in the last decades underlined the critical need for global health frameworks, as these viruses displayed a concerning propensity for cross-border transmission, escalating into worldwide health emergencies. The COVID-19 pandemic, which emerged in late 2019, dramatically shifted the focus of public health strategies, underlining one more time the necessity of clinical research into viral mutations and the importance of healthcare system preparedness. The unprecedented global collaboration to develop vaccines in record time showcased the power of international partnership in addressing such crises. The pandemic also underscored the necessity of equitable vaccine distribution to achieve global herd immunity.

Conclusion: Through a detailed analysis of past and present pandemics, this review underscores the vital importance of early detection systems, swift response mechanisms, and sustained global cooperation aimed at minimizing the public health, social, and economic ramifications of future viral outbreaks. The findings emphasize that continuous research, enhanced surveillance methodologies, and strategic emergency preparedness plans are essential to effectively combat emerging viral threats and safeguard public health worldwide.

 


Keywords


pandemic, respiratory viruses, coronavirus, covid pandemic

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References


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