The frequency and correlation of autoimmune endocrine diseases in adolescent patients

Nino Turashvili, Lali Javashvili, Elene Giorgadze

Abstract


     Autoimmune endocrine diseases are widespread problem nowadays; Autoimmune endocrinopathies often occur together in the same person and are cluster as autoimmune polyglandular diseases. Mostly one autoimmune endocrine disorder develops clinically earlier than other. 

     According to the articles, published in the Pubmed and Google Scholar database, between several autoimmune endocrine diseases autoimmune diabetes and autoimmune thyroid diseases coincidence often together, most likely due to shared genetic predisposition . Indeed several loci and genes have been shown to contribute to the joint susceptibility to autoimmune diabetes and autoimmune thyroid diseases . Early identification and treatment of another autoimmune endocrine disease is very important  and sometimes even life-saving . Early identification autoimmune thyroid disease when autoimmune diabetes is already diagnosed is recommended  according new guidelines.  


Keywords


Autoimmune endocrine diseases; autoimmune diabetes; autoimmune thyroid diseases;

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References


Medawar PB. Immunological tolerance. Science. 1961 Feb 3;133(3449):303-6.

"The Immune System: In Defence of our Lives". Nobelprize.org. Nobel Media AB 2014. http://www.nobelprize.org/educational/medicine/immuneresponses/overview/

Huber A, Menconi F, Corathers S, Jacobson EM, Tomer Y. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocrine Reviews. 2008 Oct;29(6):697-725.

Shoback DG, Gardner G. Dolores .Greenspan's basic & clinical endocrinology. 9 th Edition 2011: 35-44; 588-599; ISSN 0891-2068; ISBN 978-0-07-162243-1; MHID 0-07-162243-8;

Betterle C, Lazzarotto F, Presotto F. Autoimmune polyglandular syndrome Type 2: the tip of an iceberg?. Clinical & Experimental Immunology. 2004 Aug 1;137(2):225-33.

Kasznicki J, Drzewoski J. A case of autoimmune urticaria accompanying autoimmune polyglandular syndrome type III associated with Hashimoto’s disease, type 1 diabetes mellitus, and vitiligo. Endokrynologia Polska. 2014 Jan 1;65(4):320-3.

Ben-Skowronek I, Michalczyk A, Piekarski R, Wysocka-Lukasik B, Banecka B. Type III Polyglandular Autoimmune Syndromes in children with type 1 diabetes mellitus. Annals of Agricultural and Environmental Medicine. 2013;20(1).

Eisenbarth GS, Gottlieb PA. Autoimmune polyendocrine syndromes. New England Journal of Medicine. 2004 May 13;350(20):2068-79.

Yokoi N, Hidaka S, Tanabe S, Ohya M, Ishima M, Takagi Y, Masui N, Seino S. Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats. Genes and immunity. 2012 Feb 1;13(2):139-45.

Rosenbloom A, Silverstein J. Type 2 diabetes in children and adolescents: A guide to diagnosis, epidemiology, pathogenesis, prevention, and treatment. American Diabetes Association; 2003 May 1.

Villano MJ, Huber AK, Greenberg DA, Golden BK, Concepcion E, Tomer Y. Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families. The Journal of Clinical Endocrinology & Metabolism. 2009 Apr;94(4):1458-66.

Grzelka A, Araszkiewicz A, Uruska A, Zozulińska-Ziółkiewicz D. Prevalence of anti-thyroid peroxidase in adults with type 1 diabetes participating in Poznan Prospective Study. Advances in clinical and experimental medicine: official organ Wroclaw Medical University. 2014 Dec;24(1):79-84.

Van den Driessche A, Eenkhoorn V, Van Gaal L, De Block C. Type 1 diabetes and autoimmune polyglandular syndrome: a clinical review. Neth J Med. 2009 Dec 1;67(11):376-87.

Somers EC, Thomas SL, Smeeth L, Hall AJ. Are individuals with an autoimmune disease at higher risk of a second autoimmune disorder?. American journal of epidemiology. 2009 Mar 15;169(6):749-55.

Kahles H, Fain PR, Baker P, Eisenbarth G, Badenhoop K. Genetics of autoimmune thyroiditis in type 1 diabetes reveals a novel association with DPB1* 0201: data from the Type 1 Diabetes Genetics Consortium. Diabetes Care. 2015 Oct 1;38(Supplement 2):S21-8.

Szepietowska B, Wawrusiewicz-Kurylonek N, Krętowski A, Górska M, Szelachowska M. PRACE ORYGINALNE/ORIGINAL PAPERS Endocrine autoimmunity in patients with Latent Autoimmune Diabetes in Adults (LADA)–association with HLA genotype Występowanie chorób autoimmunologicznych u pacjentów z późno ujawniającą się cukrzycą autoimmunologiczną u osób dorosłych–związek z genotypem HLA. Endokrynol Pol. 2016;67(2):197-201.

Marathe PH, Gao HX, Close KL. American Diabetes Association Standards of Medical Care in Diabetes 2017. Journal of Diabetes. 2017 Jan 1.




DOI: http://dx.doi.org/10.29088//TCM-GMJ.2017.28

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