Amyloid and Tau-based therapeutics
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Amyloid and Tau-based therapeutics |
| 2. | Creator | Author's name, affiliation, country | David Evsia |
| 2. | Creator | Author's name, affiliation, country | Mariam Gigauri |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | |
| 4. | Description | Abstract | Alzheimer’s disease is a progressive neurodegenerative disorder characterized by declining memory, cognitive functions, and behavior. Two key pathological proteins involved are amyloid-beta (Aβ) and tau. Recent research focuses on therapies targeting these proteins, such as monoclonal antibodies like Lecanemab and Donanemab, to reduce Aβ plaques. Tau-targeted treatments aim to minimize phosphorylation or prevent tau aggregation. The presentation reviews the molecular mechanisms of Aβ and tau, emerging therapeutic strategies, recent clinical data, and challenges in safety and treatment personalization. |
| 5. | Publisher | Organizing agency, location | Ivane Javakhishvili Tbilisi State University |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (YYYY-MM-DD) | 2025-08-30 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | http://tcm.tsu.ge/index.php/TCM-GMJ/article/view/589 |
| 11. | Source | Title; vol., no. (year) | Translational and Clinical Medicine - Georgian Medical Journal; Vol 10, No 1 (2025): Supplementary Issue: International Conference in Translational and Clinical Medicine – „Neurodegenerative diseases”, 14-15, June, 2025, Tbilisi, Georgia |
| 12. | Language | English=en | |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2025 Translational and Clinical Medicine - Georgian Medical Journal |