VDR Fokl rs2228570 SNP in Autoimmune Thyroiditis

Aleena Parveen Shaikh, Rajneesh Khurana, Megi Inaishvili, Nameera Parveen Shaikh, Salome Glonti, Nino Kedelidze, Irina Nakashidze

Abstract


Autoimmune thyroiditis disease (AITD) is a widespread autoimmune pathology. Notably, Genetics factors have a kye contribution to the clinico-pathogenesis of AITD. It's suggested that several immune-related genes have been implicated in genetic susceptibility to AIT.  Vitamin D receptor (VDR) and its system is involved in an orchestrated mechanism of inflammatory response that leads to autoimmunity. In this review, we summarize together the VDR Fokl rs2228570 SNP in autoimmune thyroiditis. Based on the literature review, we have concluded that rs2228570 SNP may have susceptibility and predisposition to develop AITD.


Keywords


Autoimmune Thyroiditis, Vitamin D polymorphism, FokI, rs2228570.

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