TRANSLATIONAL AND CLINICAL MEDICINE - Georgian Medical Journal

Both pharmacological and non-pharmacological interventions play a critical role in the management of Alzheimer’s disease. Current pharmacological treatments, including cholinesterase inhibitors and NMDA receptor antagonists, offer only symptomatic relief and do not modify the underlying disease process. In contrast, non-pharmacological strategies—such as cognitive training, physical activity, and psychosocial interventions—have demonstrated promising effects on cognitive performance and overall well-being. Emerging evidence suggests that a combined, multidisciplinary approach yields more substantial and sustained benefits than either strategy alone. Therefore, integrating pharmacological and non-pharmacological modalities is essential for optimizing patient outcomes in Alzheimer’s disease care