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Email this article The role of somatic polyploidy in various liver pathologies in rats
Abstract
Introduction: Polyploidy is a widespread phenomenon in nature multiple increased content of the chromosomes 4n, 8n, 16n, etc). The frequency of its occurrence varies in different classes of organisms. The highest ploidy characterizes protozoans. Polyploid is relatively rare in multicellular organisms, among which such hermaphrodites are distinguished with the content of high-ploidic cells as for example mollusks (128n). The plant and animal bodies stand in marked contrast in terms of poliploydy as well. High vitality and fertility of polyploidic plants provided the basis for the process of applying high ploidic plants as the raw material in the selection. In case of mammals, polyploidy is most intensively studied in on the example of the liver, as it belongs to that small number of organs, for which normally characteristic polyploidy is described in all species. At the same time, polyploidization is a process initiated in the destructive tissue of liver in the conditions of various pathologies. Despite this, biological importance of polyploidy and its signaling pathways are not yet fully studied.
Method: We have reviewed literature in the next scientific databases: PubMed and Google Scholar. Articles were browsed by using advance search tools and filtered all open accessed articles with next keywords in title and/or abstract: Liver Regeneration; Liver cell, Polyploidy; Liver pathologies; Liver injury; Pathways, mechanism of poliploidy.
Conclusion: According to several hypotheses in literature, polyploidy is associated with maturation of hepatocytes and terminal differentiation protects against oxidative stress and damages caused by various pathogens and increase the functional activity of hepatocytes. Comparative study of interconnected cascade signaling pathways, averaged by protein kinases, regulating liver restoration under normal and pathological conditions by using various experimental models.
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Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology. 2006 Feb;43(S1):S45-53.
Michalopoulos GK. Liver regeneration. Journal of cellular physiology. 2007 Nov 1;213(2):286-300.
Bivalkevich N. Karaman U. Mechanisms of Rats Liver Regeneration During Alimentary Dyslipidemic Health. Medical ecology. The science. 2009 e4-5 (pp38-40) ; (Russia)
Wang MJ, Chen F, Lau JT, Hu YP. Hepatocyte polyploidization and its association with pathophysiological processes. Cell death & disease. 2017 May;8(5):e2805.
Bakuradze E The characteristics of the liver regeneration in conditions of cholestasis. The thesis for gaining degree of candidate of biological sciences. 2006; (Georgia)
Minamishima YA, Nakayama K, Nakayama KI. Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. Cancer Research. 2002 Feb 15;62(4):995-9
Losick VP. Wound-induced polyploidy is required for tissue repair. Advances in wound care. 2016 Jun 1;5(6):271-8.
Ramsey J, Schemske DW. Pathways, mechanisms, and rates of polyploid formation in flowering plants. Annual review of ecology and systematics. 1998 Nov;29(1):467-501.
Otto SP. The evolutionary consequences of polyploidy. Cell. 2007 Nov 2;131 (3):452-62.
Anatskaya OV, Vinogradov AE, Kudryavtsev BN. Hepatocyte polyploidy and metabolism/life-history traits: hypotheses testing. Journal of theoretical biology. 1994 May 21;168(2):191-9.
Geschwind II, Alfert M, Schooley C. The effects of thyroxin and growth hormone on liver polyploidy. The Biological Bulletin. 1960 Feb;118(1):66-9.
Nadal C, Zajdela F. Polyploïdie somatique dans le foie de rat: I. Le rôle des cellules binucléées dans la genèse des cellules polyploïdes. Experimental Cell Research. 1966 Apr 1;42(1):99-116.
Brodsky V, Uryvaeva I.V. Cell polyploidy. Proliferation and differentiation. Nauca. Moscow.1981. p259.(Russia)
Saeter G, Schwarze PE, Nesland JM, Juul N, Pettersen EO, Seglen PO. The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas. Carcinogenesis. 1988 Jun 1;9(6):939-45.
Gerlyng P, Åbyholm A, Grotmol T, Erikstein B, Huitfeldt HS, Stokke T, Seglen PO. Binucleation and polyploidization patterns in developmental and regenerative rat liver growth. Cell proliferation. 1993 Nov;26(6):557-65.
Gentric G, Desdouets C. Polyploidization in liver tissue. The American journal of pathology. 2014 Feb 1;184(2):322-31.
Lejava T. Human Genetics. General parts of Edition of TSU 1989. pp 153- 155 (Georgia)
Li F, Wang X, Capasso JM, Gerdes AM. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. Journal of molecular and cellular cardiology. 1996 Aug 1;28(8):1737-46.
Ulumbekov E. Histology. Pathology processes. 1998. pp393-400 (Russia)
Shatirishvili A. Tsagareli S. Tsartsidze M. General Biology. Tbilisi 1999. pp 305-306 (Georgia)
Krstic RV. Illustrated encyclopedia of human histology. Springer Science & Business Media; 2012 Dec 6.
Duelli D, Lazebnik Y. Cell-to-cell fusion as a link between viruses and cancer. Nature Reviews Cancer. 2007 Dec;7(12):968.
Gupta S. Hepatic polyploidy and liver growth control. InSeminars in cancer biology 2000 Jun 1 (Vol. 10, No. 3, pp. 161-171). Academic Press.
Kudryavtsev BN, Kudryavtseva MV, Sakuta GA, Stein GI. Human hepatocyte polyploidization kinetics in the course of life cycle. Virchows Archiv B. 1993 Dec 1;64(1):387.
Guidotti JE, Brégerie O, Robert A, Debey P, Brechot C, Desdouets C. Liver cell polyploidization: a pivotal role for binuclear hepatocytes. Journal of Biological Chemistry. 2003 May 23;278(21):19095-101.
Celton-Morizur S, Merlen G, Couton D, Margall-Ducos G, Desdouets C. The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents. The Journal of clinical investigation. 2009 Jul 1;119(7):1880-7.
Leffert HL, Koch KS, Moran T, Rubalcava B. Hormonal control of rat liver regeneration. Gastroenterology. 1979 Jun 1;76(6):1470-82.
Kelley-Loughnane N, Sabla GE, Ley-Ebert C, Aronow BJ, Bezerra JA. Independent and overlapping transcriptional activation during liver development and regeneration in mice. Hepatology. 2002 Mar 1;35(3):525-34.
Gentric G, Celton-Morizur S, Desdouets C. Polyploidy and liver proliferation. Clinics and research in hepatology and gastroenterology. 2012 Feb 1;36 (1):29-34.
Giridhar R. Gorla,Harmeet Malhi,Sanjeev Gupta Polyploidy associated with oxidative injury attenuates proliferative potential of cells. J Cell Sci 2001 Aug;114(Pt 16):2943-51;
Ohtake M, Sakaguchi T, Yoshida K, Muto T. Hepatic branch vagotomy can suppress liver regeneration in partially hepatectomized rats. HPB Surgery. 1993;6(4):277-86.
Linard C, Marquette C, Clarençon D, Galonnier M, Mathieu J, Pennequin A, Benderitter M, Gourmelon P. Acute ileal inflammatory cytokine response induced by irradiation is modulated by subdiaphragmatic vagotomy. Journal of neuroimmunology. 2005 Nov 1;168(1-2):83-95.
Qemoklidze S. Bakuradze E, Modebadze I, Dekanoidze D, Ninua L, Dzidziguri D, Influence of the Truncal Vagotomy on the liver Regeneration. Abstracts of the scientific board of 13th ESS Meeting. 2009. Octomber 4th Tbilisi, (Georgia)
DOI: http://dx.doi.org/10.29088/TCM-GMJ.2019-08
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ISSN: 2346-8491 (online)