Chemotherapy with monoclonal antibodies in treatment of Castleman’s Disease in HIV positive patient: a case report

Natia Tchkadua, Irina Eliava, Archil Aladashvili, Gia Lobzhanidze


Background: Castleman's disease (CD), a rare condition of uncertain etiology, involves a massive proliferation of lymphoid tissues. We described 31 years patient with CD who presented with diffuse adenopathy involving the inguinal, paratracheal, retroperitoneal, axillary, and pelvic regions.

Case presentation: Case report describing presentation, workup, management, and clinical course of a patient with Castleman's disease. The patient was treated with chemotherapeutic agents (Cyclophosphamide, doxorubicin, Vincristine) and monoclonal antibodies (Rituximab).

Conclusions: This case represents the CD involving an HIV-positive patient. Patients with HIV are at high risk for the development of Castleman’s disease, non-Hodgkin's lymphoma, and Kaposi sarcoma, regular medical surveillance is recommended.


Castleman's disease; Diffuse adenopathy; HIV-positive patient;

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ISSN: 2346-8491 (online)