3D Bioprinting for Enteroatmospheric Fistulae

Javier Padillo


Background:  Enteroatmospheric fistulae are challenging clinical conditions that require surgical expertise and that can result in chronic debilitating conditions placing the patient in a vicious cycle characterized by non healing wounds and malnutrition. They are a complex entity that presents great variability depending on the number, shape, and size of the fistulous orifices, their debit, and the dimensions of the wound.

This means that, at present, there is no device that adapts to the anatomical characteristics of each patient and manages to control the spillage of intestinal effluvium from the wound.

Aim: The aim of this study is to describe the manufacturing technique and to assess the preliminary results of a custom

Method: Four patients were included in the proof of concept study. Device designed through bioscanner imaging and manufactured using 3D printing for use with negative pressure wound therapy (NPWT) in the management of enteroatmospheric fistula. A proof of concept is given, and the design of the device is presented for the first time. After obtaining images of each fistula with a bioscanner, a personalised device was designed for each patient by 3D printing shape of a prism and a hollow base, taking into account the dimensions of the fistulous area in order to perform a floating ostomy to isolate the wound from the debit enteric. The polycaprolactone (PCL) device was placed including inside the fistulous surface and surrounding it with the NPWT system in order to accelerate wound healing.

Results: pain (p<0.002) pruritus (p<0.006) and the number of wound cures (p<0.001) decreased significlantly. All patients could be closed the abdominal wall.

Conclusion: The personalized device designed with bioscanner and 3D printing it is useful for patients with Enteroatmospheric fistulae.


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ISSN: 2346-8491 (online)