TRANSLATIONAL AND CLINICAL MEDICINE - Georgian Medical Journal

Introduction: Present article is aimed at discussing the efficacy of the traditional treatment of uterine sarcoma, such as surgery and chemotherapy, as well as the significance of the  expression of  programmed cell death receptor-1/ligand 1  and sex hormone receptors (estrogen and progesterone receptors) in prognosis of the uterine sarcoma outcome. Method: Data was collected using the electronic search method in the following databases: PubMed/Medline, Web of Science. Terms “Uterine sarcoma”, immunotherapy”, “Immunohystology” were utilized. Articles published between 2005-2021 were included.  Conclusion: Existing data on surgical approach vary from radical hysterectomy to fertility-preserving surgery in the form of trachelectomy or wide local excision, however no definite conclusions can be drafted on the recommended surgical approach. There is a controversy in findings concerning the prognostic value  of sex hormone (estrogen and progesterone) receptors and programmed cell death receptor-1/ligand 1 expression in the treatment of uterine sarcomas. Extension of data in this direction is necessary to throw more light to the role of truditional treatment methods and onco-immunology in the treatment of uterine sarcoma.

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