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Email this article Association between vitamin D and thyroid structural abnormalities in male patients
Abstract
Background: Structural disorder of the thyroid gland is a common endocrine problem. Several factors can contribute to the development of thyroid nodules. Vitamin D deficiency is also a widespread problem. It is a hormone, that regulates multiple signaling pathways involved in cellular proliferation, differentiation, apoptosis. The aim of our research was to determine an association between thyroid structural changes and vitamin D status in male patients in Georgia. As far as we know, this is the first research in this field in Georgia.
Methods: This retrospective study enrolled male patients, who were 18–70 years old and visited the private clinics in 2018 or in 2019 from midspring to mid-summer. Data of the serum 25(OH)D level and thyroid ultrasound characteristics was statistically analysed.
Results: From total study group 9.6% had enlarged thyroid. The vitamin D level was low in both groups (patients with normal and increased volume of thyroid gland), but not statistically significant (P =0.714). Heterogenous parenchyma was found in 67.3 % cases. The vitamin D level was low in both groups (normal and heterogenous parenchyma groups), but not statistically significant (P = 0.536). 13.5% of patients had nodular- and 11,5 % had multinodular goiter. The association between number of thyroid nodules and vitamin D levels was not statistically significant (P =0.479). There was also no association between the size of the largest nodule and vitamin D level (P =0.768). From total study group only 7% had normal vitamin D levels.
Conclusions: Any association between structural changes of thyroid glands and vitamin D levels in men was not found.
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Du X, Liu Y, Zhao C, Fang J, Wang X, Wei L. Changes of serum 25 (OH) D3 and IGF-1 levels in patients with thyroid nodules. BMC endocrine disorders. 2019 Dec 1;19(1):48.
Russ G, Leboulleux S, Leenhardt L, Hegedüs L. Thyroid incidentalomas: epidemiology, risk stratification with ultrasound and workup. European thyroid journal. 2014;3(3):154-63.
Russ G, Bonnema SJ, Erdogan MF, Durante C, Ngu R, Leenhardt L. European Thyroid Association guidelines for ultrasound malignancy risk stratification of thyroid nodules in adults: the EU-TIRADS. European thyroid journal. 2017;6(5):225-37.
Jena A, Patnayak R, Prakash J, Sachan A, Suresh V, Lakshmi AY. Malignancy in solitary thyroid nodule: A clinicoradiopathological evaluation. Indian journal of endocrinology and metabolism. 2015 Jul;19(4):498.
Tai JD, Yang JL, Wu SC, Wang BW, Chang CJ. Risk factors for malignancy in patients with solitary thyroid nodules and their impact on the management. Journal of cancer research and therapeutics. 2012 Jul 1;8(3):379.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016 Jan 1;26(1):1-33.
Zamora EA, Khare S, Cassaro S. Thyroid nodule. StatPearls [Internet]. 2020 Aug 10.
R. Cesareo, M. Iozzino, L ’D’onofrio et al., “Effectiveness and safety of calcium and vitamin D treatment for postmenopausal osteoporosis,” Minerva Endocrinologica, vol. 40, no. 3, pp. 231–237, 2015.
C. Liu, X. Kuang, K. Li, X. Guo, Q. Deng, and D. Li, “Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials,” Food & Function, vol. 11, no. 12, pp. 10817–10827, 2020.
T. Yoshida and P. H. Stern, “How vitamin D works on bone,” Endocrinology and Metabolism Clinics of North America, vol. 41, no. 3, pp. 557–569, 2012.
Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. The Journal of Clinical Endocrinology & Metabolism. 2007 Jun 1;92(6):2017-29.
Garland CF, Gorham ED, Mohr SB, Garland FC. Vitamin D for cancer prevention: global perspective. Annals of epidemiology. 2009 Jul 1;19(7):468-83.
Leyssens C, Verlinden L, Verstuyf A. Antineoplastic effects of 1, 25 (OH) 2D3 and its analogs in breast, prostate and colorectal cancer. Endocrine-related cancer. 2013 Apr 1;20(2):R31-47 .
X. Wang, J. Zynat, Y Guo et al., “Low serum vitamin D is associated with anti-thyroid-globulin antibody in female International Journal of Endocrinology 5 individuals,” International journal of endocrinology, vol. 2015, Article ID 285290, 2015 ;
Y. M. Choi, W. G. Kim, T. Y. Kim et al., “Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women,” 2yroid, vol. 24, no. 4, pp. 655–661, 2014.
Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nature reviews cancer. 2014 May;14(5):342-57.
I. I. Dedov, G. A. Melnichenko, and V. V. Fadeev, Endocrinology: 2e Textbook for Universities, GEOTAR-Media, Russia, 2007
M. F. Holick, N. C. Binkley, H. A. Bischoff-Ferrari et al., “Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline,” 2e Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 7, pp. 1911–1930, 2011.
Laney N, Meza J, Lyden E, Erickson J, Treude K, Goldner W. The prevalence of vitamin D deficiency is similar between thyroid nodule and thyroid cancer patients. International journal of endocrinology. 2010 Jan 1;2010.
A. C. Ross, C. L. Taylor, A. L. Yaktine, and H. B. Del Valle,“Dietary reference intakes for adequacy: calcium and vitamin D. InDietary reference intakes for calcium and vitamin D 2011,” Washington, DC, USA, 2011.
M. ˇStefani´c and S. Toki´c, “Serum 25-hydoxyvitamin D concentrations in relation to Hashimoto’s thyroiditis: a systematic review, meta-analysis and meta-regression of observational studies,” European Journal of Nutrition, vol. 59, no. 3, pp. 859–872, 2020.
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